Bartonella henselae
Vigil, A., Ortega, R., Jain, A., Nakajima-Sasaki, R., Tan, X., Chomel, B. B., Kasten, R. W., Koehler, J. E., and Felgner, P. L. (2010) Identification of the feline humoral immune response to Bartonella henselae infection by protein microarray, PLoS One 5, e11447.
Borrelia burgdorferi
Barbour, A. G., Jasinskas, A., Kayala, M. A., Davies, D. H., Steere, A. C., Baldi, P., and Felgner, P. L. (2008) A genome-wide proteome array reveals a limited set of immunogens in natural infections of humans and white-footed mice with Borrelia burgdorferi, Infect Immun 76, 3374-3389.
Brucella melitensis
Liang, L., Leng, D., Burk, C., Nakajima-Sasaki, R., Kayala, M. A., Atluri, V. L., Pablo, J., Unal, B., Ficht, T. A., Gotuzzo, E., Saito, M., Morrow, W. J., Liang, X., Baldi, P., Gilman, R. H., Vinetz, J. M., Tsolis, R. M., and Felgner, P. L. (2010) Large scale immune profiling of infected humans and goats reveals differential recognition of Brucella melitensis antigens, PLoS Negl Trop Dis 4, e673.
Liang, L., Tan, X., Juarez, S., Villaverde, H., Pablo, J., Nakajima-Sasaki, R., Gotuzzo, E., Saito, M., Hermanson, G., Molina, D., Felgner, S., Morrow, W. J., Liang, X., Gilman, R. H., Davies, D. H., Tsolis, R. M., Vinetz, J. M., and Felgner, P. L. (2011) Systems biology approach predicts antibody signature associated with Brucella melitensis infection in humans, J Proteome Res 10, 4813-4824.
Cannella, A. P., Lin, J. C., Liang, L., Atluri, V., Gotuzzo, E., Felgner, P. L., Tsolis, R. M., and Vinetz, J. M. (2012) Serial Kinetics of the Antibody Response against the Complete Brucella melitensis ORFeome in Focal Vertebral Brucellosis, J Clin Microbiol 50, 922-926.
Cannella, A.P., Tsolis, R.M., Liang, L., Felgner, P.L., Saito, M., Sette, A., Gotuzzo, E., and Vinetz, J.M. (2012) Antigen-specific acquired immunity in human brucellosis: implications for diagnosis, prognosis, and vaccine development, Frontiers in Cellular and Infection Microbiology 01/2012; 2:1.
Cannella, A.P., Arlehamn, C.S.L., Sidney, J., Patra, K.P., Torres, K., Tsolis, R.M., Liang, L., Felgner, P.L., Saito, M., Gotuzzo, E., Gilman, R.H., Sette, A., and Vinetz, J.M. (2013) Brucella melitensis T cell Epitope Recognition by Humans Recovered From Brucellosis in Peru, Infection and immunity 10/2013.
Burkholderia pseudomallei:
Felgner, P. L., Kayala, M. A., Vigil, A., Burk, C., Nakajima-Sasaki, R., Pablo, J., Molina, D. M., Hirst, S., Chew, J. S., Wang, D., Tan, G., Duffield, M., Yang, R., Neel, J., Chantratita, N., Bancroft, G., Lertmemongkolchai, G., Davies, D. H., Baldi, P., Peacock, S., and Titball, R. W. (2009) A Burkholderia pseudomallei protein microarray reveals serodiagnostic and cross-reactive antigens, Proc Natl Acad Sci U S A 106, 13499-13504.
Tippayawat, P., Saenwongsa, W., Mahawantung, J., Suwannasaen, D., Chetchotisakd, P., Limmathurotsakul, D., Peacock, S. J., Felgner, P. L., Atkins, H. S., Titball, R. W., Bancroft, G. J., and Lertmemongkolchai, G. (2009) Phenotypic and functional characterization of human memory T cell responses to Burkholderia pseudomallei, PLoS Negl Trop Dis 3, e407.
Yang, Z. R., Lertmemongkolchai, G., Tan, G., Felgner, P. L., and Titball, R. (2009) A genetic programming approach for Burkholderia pseudomallei diagnostic pattern discovery, Bioinformatics 25, 2256-2262.
Tippayawat, P., Pinsiri, M., Rinchai, D., Riyapa, D., Romphruk, A., Gan Y-H., Houghton, R.L., Felgner, P.L., Titball, R.W., Stevens, M.P., Galyov, E.E., Bancroft, G.J., and Lertmemongkolchai, G. (2010). Burkholderia pseudomallei proteins presented by monocyte-derived dendritic cells stimulate human memory T cells in vitro, Infection and immunity 11/2010; 79(1):305-13.
Suwannasaen, D., Mahawantung, J., Chaowagul, W., Limmathurotsakul, D., Felgner, P. L., Davies, H., Bancroft, G. J., Titball, R. W., and Lertmemongkolchai, G. (2011) Human immune responses to Burkholderia pseudomallei characterized by protein microarray analysis, J Infect Dis 203, 1002-1011.
Conejero, L., Patel, N., de Reynal, M., Oberdorf, S., Prior, J., Felgner, P. L., Titball, R. W., Salguero, F. J., Bancroft, G. J. (2011) Low-dose exposure of C57BL/6 mice to Burkholderia pseudomallei mimics chronic human melioidosis, Am J Pathol 179, 270-280.
Varga, J.J., Vigil, A., Deshazer, D., Waag, D.M., Felgner, P.L., and Goldberg, and J.B. (2012) Distinct human antibody response to the biological warfare agent Burkholderia mallei, Virulence 10/2012; 3(6)
Candidemia
Mochon, A. B., Ye, J., Kayala, M. A., Wingard, J. R., Clancy, C. J., Nguyen, M. H., Felgner, P., Baldi, P., and Liu, H. (2010) Serological profiling of a Candida albicans protein microarray reveals permanent host-pathogen interplay and stage-specific responses during candidemia, PLoS Pathog 6(9), e1000827.
Chlamydia trachomatis
Molina, D. M., Pal, S., Kayala, M. A., Teng, A., Kim, P. J., Baldi, P., Felgner, P. L., Liang, X., and de la Maza, L. M. (2010) Identification of immunodominant antigens of Chlamydia trachomatis using proteome microarrays, Vaccine 28, 3014-3024.
Cruz-Fisher MI, Cheng C, Sun G, Pal S, Teng A, Molina DM, Kayala MA, Vigil A, Baldi P, Felgner PL, Liang X, de la Maza LM. (2011) Identification of immunodominant antigens by hybridization a whole Chlamydia trachomatis open reading frame proteome microarray using sera from immunized mice, Infect Immun, 79(1):246-57.
Teng, A., Cruz-Fisher, M.I., Cheng, C., Pal. S., Sun, G., Ralli-Jain, P., Molina, D.M., Felgner, P.L. , Liang, X., and de la Maza, L.M. (2012) Proteomic identification of immunodominant chlamydial antigens in a mouse model, Journal of proteomics 08/2012
Cheng, C., Jain, P., Pal, S., Tifrea, D., Sun, G, Teng, A., Liang, X., Felgner, P.L., and de la Maza, L.M. (2013) Assessment of the role in protection and pathogenesis of the Chlamydia muridarum V-type ATP synthase subunit A (AtpA) (TC0582), Microbes and Infection 10/2013.
Patton, D.L., Teng, A., Randall, A., Liang, X., Felgner, P.L., and de la Maza, L.M. (2014) Whole genome identification of C. trachomatis immunodominant antigens after genital tract infections and effect of antibiotic treatment of pigtailed macaques, Journal of proteomics. 05/2014.
Coxiella burnetii
Beare, P. A., Chen, C., Bouman, T., Pablo, J., Unal, B., Cockrell, D. C., Brown, W. C., Barbian, K. D., Porcella, S. F., Samuel, J. E., Felgner, P. L., and Heinzen, R. A. (2008) Candidate Q fever serodiagnostic antigens revealed by immunoscreening a Coxiella burnetii protein microarray, Clin Vaccine Immunol. (12):1771-9.
Chen, C., Bouman, T. J., Beare, P. A., Mertens, K., Zhang, G. Q., Russell-Lodrigue, K. E., Hogaboam, J. P., Peters, B., Felgner, P. L., Brown, W. C., Heinzen, R. A., Hendrix, L. R., and Samuel, J. E. (2009) A systematic approach to evaluate humoral and cellular immune responses to Coxiella burnetii immunoreactive antigens, Clin Microbiol Infect 15 Suppl 2, 156-157
Vigil, A., Ortega, R., Nakajima-Sasaki, R., Pablo, J., Molina, D. M., Chao, C. C., Chen, H. W., Ching, W. M., and Felgner, P. L. (2010) Genome-wide profiling of humoral immune response to Coxiella burnetii infection by protein microarray, Proteomics 10, 2259-2269.
Vigil, A., Chen, C., Jain, A., Nakajima-Sasaki, R., Jasinskas, A., Pablo, J., Hendrix, L. R., Samuel, J. E., Felgner, P. L. (2011) Profiling the humoral immune response of acute and chronic Q fever by protein microarray, Mol Cell Proteomics 10(10): M110.006304
Cytauxzoon
Tarigo, J.L., Scholl, E.H., Bird, D.M., Brown, C.C., Cohn, L.A., Dean, G.A., Levy, M.G., Doolan, D.L., Trieu, A., Nordone, S.K., Felgner, P.L., Vigil, A., and Birkenheuer, A.J. (2013) A novel candidate vaccine for cytauxzoonosis inferred from comparative apicomplexan genomics, PLoS ONE 01/2013; 8(8):e71233.
Francisella tularensis
Isherwood, K. E., Titball, R. W., Davies, D. H., Felgner, P. L., and Morrow, W. J. (2005) Vaccination strategies for Francisella tularensis, Adv Drug Deliv Rev 57, 1403-1414.
Eyles, J. E., Unal, B., Hartley, M. G., Newstead, S. L., Flick-Smith, H., Prior, J. L., Oyston, P. C., Randall, A., Mu, Y., Hirst, S., Molina, D. M., Davies, D. H., Milne, T., Griffin, K. F., Baldi, P., Titball, R. W., and Felgner, P. L. (2007) Immunodominant Francisella tularensis antigens identified using proteome microarray, Proteomics 7, 2172-2183.
Lu, Z., Roche, M. I., Hui, J. H., Unal, B., Felgner, P. L., Gulati, S., Madico, G., and Sharon, J. (2007) Generation and characterization of hybridoma antibodies for immunotherapy of tularemia, Immunol Lett 112, 92-103.
Sundaresh, S., Randall, A., Unal, B., Petersen, J. M., Belisle, J. T., Gill Hartley, M., Duffield, M., Titball, R. W., Davies, D. H., Felgner, P. L., and Baldi, P. (2007) From protein microarrays to diagnostic antigen discovery: a study of the pathogen Francisella tularensis, Bioinformatics 23, i508-i518.
HIV
Dotsey, E.Y, Gorlani, A., Ingale, S., Achenbach, C.J., Forthal, D.N., Felgner, P.L., and Gach, J.S. (2015) A High Throughput Protein Microarray Approach to Classify HIV Monoclonal Antibodies and Variant Antigens, PLoS ONE 05/2015; 10(5). DOI:10.1371/journal.pone.0125581.
HPV
Luevano, M., Bernard, H. U., Barrera-Saldana, H. A., Trevino, V., Garcia-Carranca, A., Villa, L. L., Monk, B. J., Tan, X., Davies, D. H., Felgner, P. L., and Kalantari, M. (2010) High-throughput profiling of the humoral immune responses against thirteen human papillomavirus types by proteome microarrays, Virology 405(1):31-40.
HSV
Kalantari-Dehaghi, M., Chun, S., Chentoufi, A., Pablo, J., Liang, L., Dasgupta, G., Molina, D. M., Jasinskas, A., Nakajima-Sasaki, R., Felgner, J., Hermanson, G., Benmohamed, L., Felgner, P. L., and Davies, D. H. (2012) Discovery of potential diagnostic and vaccine antigens in herpes simplex virus-1 and -2 by proteome-wide antibody profiling, J Virol. 86(8):4328-39
Dasgupta, G., Chentoufi, A. A., Kalantari, M., Falatoonzadeh, P., Chun, S., Lim, C. H., Felgner, P. L., Davies, D. H., and Benmohamed, L. (2012) Immunodominant “Asymptomatic” Herpes Simplex Virus Type 1 and Type 2 Protein Antigens Identified by Probing Whole ORFome Microarrays By Serum Antibodies From Seropositive Asymptomatic Versus Symptomatic Individuals, J Virol. 86(8):4358-69
Leptospirosis
Lessa-Aquino, C, Rodrigues, C.B., Pablo, J., Sasaki, R., Jasinskas, A., Liang, L., Wunder, E.A., Ribeiro G.S., Vigil, A., Galler, R., Molina, D.M., Liang, X., Reis, M.G., Ko, A.I., Medeiros, M.A., Felgner, and P.L. (2013) Identification of Seroreactive Proteins of Leptospira interrogans Serovar Copenhageni Using a High-Density Protein Microarray Approach, PLoS Neglected Tropical Diseases 01/2013; 7(10):e2499.
Lessa-Aquino, C., Wunder, Jr.E.A., Lindow, J.C., Rodrigues, C.B.,Pablo, J., Nakajima, R., Jasinskas, A., Liang, L., Reis, M.G., Ko, A.I., Medeiros, M.A., and Felgner, P.L. (2014) Proteomic Features Predict Seroreactivity against Leptospiral Antigens in Leptospirosis Patients, Journal of Proteome Research 7/2014.
Malaria
Doolan, D. L., Aguiar, J. C., Weiss, W. R., Sette, A., Felgner, P. L., Regis, D. P., Quinones-Casas, P., Yates, J. R., 3rd, Blair, P. L., Richie, T. L., Hoffman, S. L., and Carucci, D. J. (2003) Utilization of genomic sequence information to develop malaria vaccines, J Exp Biol 206, 3789-3802.
Doolan, D. L., Mu, Y., Unal, B., Sundaresh, S., Hirst, S., Valdez, C., Randall, A., Molina, D., Liang, X., Freilich, D. A., Oloo, J. A., Blair, P. L., Aguiar, J. C., Baldi, P., Davies, D. H., and Felgner, P. L. (2008) Profiling humoral immune responses to P. falciparum infection with protein microarrays, Proteomics 8, 4680-4694.
Crompton, P. D., Kayala, M. A., Traore, B., Kayentao, K., Ongoiba, A., Weiss, G. E., Molina, D. M., Burk, C. R., Waisberg, M., Jasinskas, A., Tan, X., Doumbo, S., Doumtabe, D., Kone, Y., Narum, D. L., Liang, X., Doumbo, O. K., Miller, L. H., Doolan, D. L., Baldi, P., Felgner, P. L., and Pierce, S. K. (2010) A prospective analysis of the Ab response to Plasmodium falciparum before and after a malaria season by protein microarray, Proc Natl Acad Sci U S A 107, 6958-6963.
Trieu, A., Kayala, M. A., Burk, C., Molina, D. M., Freilich, D. A., Richie, T. L., Baldi P., Felgner, P. L., and Doolan, D. L. (2011) Sterile protective immunity to malaria is associated with a panel of novel P. falciparum antigens, Mol Cell Proteomics, 10(9):M111.007948.
Tan, X., Traore, B., Kayentao, K., Ongoiba, A., Doumbo, S., Waisberg, M., Doumbo, O. K., Felgner, P. L., Fairhurst, R. M., and Crompton, P. D. (2011) Hemoglobin S and C heterozygosity enhances neither the magnitude nor breadth of antibody responses to a diverse array of Plasmodium falciparum antigens, J Infect Dis 204, 1750-1761.
Nnedu, O. N., O’Leary, M. P., Mutua, D., Mutai, B., Kalantari-Dehaghi, M., Jasinskas, A., Nakajima-Sasaki, R., John-Stewart, G., Otieno, P., Liang, X., Waitumbi, J., Kimani, F., Camerini, D., Felgner, P. L., Walson, J. L., and Vigil, A. (2011) Humoral immune responses to Plasmodium falciparum among HIV-1-infected Kenyan adults, Proteomics, Clinical applications 5, 613-623.
Barry, A. E., Trieu, A., Fowkes, F. J., Pablo, J., Kalantari-Dehaghi, M., Jasinskas, A., Tan, X., Kayala, M. A., Tavul, L., Siba, P. M., Day, K. P., Baldi, P., Felgner, P. L., and Doolan, D. L. (2011) The stability and complexity of antibody responses to the major surface antigen of Plasmodium falciparum are associated with age in a malaria endemic area, Molecular & Cellular Proteomics; 10(11):M111.008326.
Molina, D. M., Finney, O. C., Arevalo-Herrera, M., Herrera, S., Felgner, P. L., Gardner, M. J., Liang, X., and Wang, R. (2012) Plasmodium vivax Pre-Erythrocytic–Stage Antigen Discovery: Exploiting Naturally Acquired Humoral Responses, Am. J. Trop. Med Hyg 87(3):460-469.
Travassos, M.A., Niangaly, A., Bailey, J.A., Ouattara, A., Coulibaly, D., Laurens, M.B., Pablo, J., Jasinskas, A., Nakajima-Sasaki, R., Berry, A.A., Takala-Harrison, S., Kouriba, B., Rowe, J.A., Lyke, K.E., Doumbo, O.K., Thera, M.A., Felgner, P.L., and Plowe, C.V. (2013) Seroreactivity to the PfEMP1 intracellular domain in malaria-exposed children and adults, The Journal of Infectious Diseases 07/2013.
Felgner, P.L., Roestenberg, M., Liang, L., Hung, C., Jain, A., Pablo, J., Nakajima-Sasaki, R., Molina, D., Teelen, K., Hermsen, C.C., and Sauerwein, R. (2013) Pre-erythrocytic antibody profiles induced by controlled human malaria infections in healthy volunteers under chloroquine prophylaxis, Scientific Reports 01/2013; 3:3549.
Baum, E., Badu, K., Molina, D.M., Liang, X., Felgner, P.L., and Yan, G (2013) Protein Microarray Analysis of Antibody Responses to Plasmodium falciparum in Western Kenyan Highland Sites with Differing Transmission Levels, PLoS ONE 01/2013; 8(12):e82246.
Finney, O.C., Danziger, S.A., Molina, D.M., Vignali, M., Takagi, A., Ji, M., Stanisic, D.I., Siba, P.M., Liang, X., Aitchison, J.D., Mueller, I., Gardner, M.J., and Wang, R. (2014) Predicting anti-disease immunity using proteome arrays and sera from children naturally exposed to malaria, Molecular & cellular proteomics : MCP. 07/2014.
Bailey, J.A., Pablo, J., Niangaly, A., Travassos, M.A., Ouattara, A., Coulibaly, D., Laurens, M.B., Takala-Harrison, S.L., Lyke, K.E., Skinner, J., Berry, A.A., Jasinskas, A., Nakajima-Sasaki, R., Kouriba, B., Thera, M.A., Felgner, P.L., Doumbo, O.K., and Plowe, C.V. (2014) Seroreactivity to a Large Panel of Field-Derived Plasmodium falciparum Apical Membrane Antigen 1 and Merozoite Surface Protein 1 Variants Reflects Seasonal and Lifetime Acquired Responses to Malaria, The American journal of tropical medicine and hygiene 10/2014.
Torres, K.J., Castrillon, C.E., Moss, E.L., Saito, M., Tenorio, R., Molina, D.M., Davies, H., Neafsey, D.E., Felgner, P.L., Vinetz, J.M., and Gamboa, D. (2014) Genome-Level Determination of Plasmodium falciparum Blood Stage Targets of Malarial Clinical Immunity in the Peruvian Amazon, The Journal of Infectious Diseases 10/2014.
Frosch, A.E.P., and John, C. (2014) Editorial: Expanding the toolbox in pursuit of a strain transcendent Malaria vaccine, The American journal of tropical medicine and hygiene 11/2014.
Campo, J.J., Aponte, J.J., Skinner, J., Nakajima, R., Molina, D.M., Liang, L., Sacarlal, J., Alonso, P.L., Crompton, P.D., Felgner, P.L., and Dobaño, C. (2015) RTS,S Vaccination Is Associated With Serologic Evidence of Decreased Exposure to Plasmodium falciparum Liver- and Blood-Stage Parasites, Molecular & Cellular Proteomics 12/2014; 14(3). DOI:10.1074/mcp.M114.044677.
Dent, A.E., Nakajima, R., Liang, L., Baum, E., Moormann, A.M., Sumba, P.O., Vulule, J., Babineau, D., Davies, D.H., Felgner, P.L., and Kazura, J.W. (2015) Plasmodium falciparum Protein Microarray Antibody Profiles Correlate With Protection From Symptomatic Malaria in Kenya, The Journal of Infectious Diseases 04/2015; DOI:10.1093/infdis/jiv224.
Travassos, M.A., Coulibaly, D., Bailey, J.A., Niangaly, A., Adams, M., Nyunt, M.M., Ouattara, A., Lyke, K.E., Laurens, M.B., Pablo, J., Jasinskas, A., Nakajima, R., Berry, A.A., Takala-Harrison, S., Kone, A.K., Kouriba, B., Rowe, J.A., Doumbo, O.K., Thera, M.A., Laufer, M.K., Felgner, P.L., and Plowe, C.V. (2015) Differential Recognition of Terminal Extracellular Plasmodium falciparum VAR2CSA Domains by Sera from Multigravid, Malaria-Exposed Malian Women, The American journal of tropical medicine and hygiene 04/2015; 92(6). DOI:10.4269/ajtmh.14-0524.
Lo, E., Zhou, G., Oo, W., Lee, M.C., Baum, E., Felgner, P.L., Yang, Z., Cui, L., and Yan, G. (2015) Molecular inference of sources and spreading patterns of Plasmodium falciparum malaria parasites in internally displaced persons settlements in Myanmar-China Border area, Infection, genetics and evolution: journal of molecular epidemiology and evolutionary genetics in infectious diseases 05/2015; 33. DOI:10.1016/j.meegid.2015.05.002.
Chen, J-H., Chen, S-B., Wang, Y., Ju, C., Zhang, T., Xu, B., Shen, H-M., Mo, X-J., Molina, D.M., Eng, M., Liang, X., Gardner, M.J., Wang, R., Hu, W. (2015) An immunomics approach for the analysis of natural antibody responses to Plasmodium vivax infection, Molecular BioSystems 06/2015; 11(8). DOI:10.1039/C5MB00330J.
Chuquiyauri, R., Molina, D.M., Moss, E.L., Wang, R., Gardner, M.J., Brouwer, K.C., Torres, S., Gilman, R.H., Llanos-Cuentas, A., Neafsey, D.E., Felgner, P.L., Liang, X., and Vinetz, J.M. (2015) Genome-Scale Protein Microarray Comparison of Human Antibody Responses in Plasmodium vivax Relapse and Reinfection, The American journal of tropical medicine and hygiene 07/2015; DOI:10.4269/ajtmh.15-0232.
Helb, D.A., Tetteh, K.K.A., Felgner, P.L., Skinner, J., Hubbard A., Arinaitwe, E., Mayanja-Kizza, H., Ssewanyana, I., Kamya, M.R., Beeson, J.G., Tappero, J., Smith, D.L., Crompton, P.D., Rosenthal, P.J., Dorsey, G., Drakeley, C.J., and Greenhouse, B. (2015) Novel serologic biomarkers provide accurate estimates of recent Plasmodium falciparum exposure for individuals and communities, Proceedings of the National Academy of Sciences 07/2015; 112(32). DOI:10.1073/pnas.1501705112.
Skinner, J., Huang, C.Y., Waisberg, M., Felgner, P.L., Doumbo, O.K., Ongoiba, A., Kayentao, K., Traore, B., Crompton, P.D., and Williamson, K.C. (2015) Plasmodium falciparum gametocyte-specific antibody profiling reveals boosting through natural infection and identifies potential markers of gametocyte exposure, Infection and Immunity 08/2015; 83(11). DOI:10.1128/IAI.00644-15.
Arama, C., Skinner, J., Doumtabe, D., Portugal, S., Tran, T.M., Jain, A., Traore, B., Doumbo, O.K., Davies, D.H., Troye-Blomberg, M., Dolo, A., Felgner, P.L., and Crompton, P.D. (2015) Genetic Resistance to Malaria Is Associated With Greater Enhancement of Immunoglobulin (Ig)M Than IgG Responses to a Broad Array of Plasmodium falciparum Antigens, The Open Infectious Diseases Journal 08/2015; 2(3). DOI:10.1093/ofid/ofv118.
Obeng-Adjei, N., Portugal, S., Tran, T.M., Yazew, T.B., Skinner, J., Li, S., Jain, A., Felgner, P.L., Doumbo, O.K., Kayentao, K., Ongoiba, A., Traore, B., Crompton, P.D. (2015) Circulating Th1-Cell-type Tfh Cells that Exhibit Impaired B Cell Help Are Preferentially Activated during Acute Malaria in Children, Cell Reports 10/2015; DOI:10.1016/j.celrep.2015.09.004.
Davies, D.H., Duffy, P., Bodmer, J-L., Felgner, P.L., and Doolan, D.L. (2015) Large screen approaches to identify novel malaria vaccine candidates, Vaccine 10/2015; DOI:10.1016/j.vaccine.2015.09.059.
Baum, E., Sattabongkot, J., Sirichaisinthop, J., Kiattibutr, K., Davies, D.H., Jain, A., Lo, E., Lee, M-C., Randall, A.Z., Molina, D.M., Liang, X., Cui, L., Felgner, P.L., and Yan G. (2015) Submicroscopic and asymptomatic Plasmodium falciparum and Plasmodium vivax infections are common in western Thailand – Molecular and serological evidence, Malaria Journal 12/2015; 14(1):611. DOI:10.1186/s12936-015-0611-9.
Mycobacterium tuberculosis
Kunnath-Velayudhan, S., Salamon, H., Wang, H. Y., Davidow, A. L., Molina, D. M., Huynh, V. T., Cirillo, D. M., Michel, G., Talbot, E. A., Perkins, M. D., Felgner, P. L., Liang, X., and Gennaro, M. L. (2010) Dynamic antibody responses to the Mycobacterium tuberculosis proteome, Proc Natl Acad Sci U S A. 107(33):14703-8.
Khan, I. H., Ravindran, R., Krishnan, V. V., Awan, I. N., Rizvi, S. K., Saqib, M. A., Shahzad, M. I., Tahseen, S., Ireton, G., Goulding, C. W., Felgner, P., DeRiemer, K., Khanum, A., and Luciw, P. A. (2011) Plasma antibody profiles as diagnostic biomarkers for tuberculosis, Clin Vaccine Immunol 18, 2148-2153.
Kunnath-Velayudhan, S., and Gennaro, M. L. (2011) Immunodiagnosis of Tuberculosis: A dynamic view of biomarker discovery, Clin Microbiology Rev 24(4):792-805.
Kunnath-Velayudhan, S., Davidow, A.L., Wang, H-Y., Molina, D.M., Huynh, V.T., Salamon, H., Pine, R., Michel, G., Perkins, M.D., Liang, X., Felgner, P.L., Flynn, J.L., Catanzaro, A., and Gennaro, M.L. (2012) Proteome-scale antibody responses and outcome of Mycobacterium tuberculosis infection in nonhuman primates and in tuberculosis patients, The Journal of Infectious Diseases 06/2012; 206(5):697-705.
Nayak, K., Jing, L., Russell, R.M., Davies, D.H., Hermanson, G., Molina, D.M., Liang, X., Sherman, D.R., Kwok, W.W., Yang, J., Kenneth, J., Ahamed, S.F., Chandele, A., Murali-Krishna, K., and Koelle, D.M. (2015) Identification of novel Mycobacterium tuberculosis CD4 T-cell antigens via high throughput proteome screening, Tuberculosis (Edinburgh, Scotland) 03/2015; 95(3). DOI:10.1016/j.tube.2015.03.001.
Orthopoxvirus
Crotty, S., Felgner, P., Davies, H., Glidewell, J., Villarreal, L., and Ahmed, R. (2003) Cutting edge: long-term B cell memory in humans after smallpox vaccination, J Immunol 171, 4969-4973.
Davies, D. H., Liang, X., Hernandez, J. E., Randall, A., Hirst, S., Mu, Y., Romero, K. M., Nguyen, T. T., Kalantari-Dehaghi, M., Crotty, S., Baldi, P., Villarreal, L. P., and Felgner, P. L. (2005) Profiling the humoral immune response to infection by using proteome microarrays: High-throughput vaccine and diagnostic antigen discovery, Proc Natl Acad Sci U S A 102, 547-552.
Davies, D. H., McCausland, M. M., Valdez, C., Huynh, D., Hernandez, J. E., Mu, Y., Hirst, S., Villarreal, L., Felgner, P. L., and Crotty, S. (2005) Vaccinia virus H3L envelope protein is a major target of neutralizing antibodies in humans and elicits protection against lethal challenge in mice, J Virol 79, 11724-11733.
Davies, D. H., Molina, D. M., Wrammert, J., Miller, J., Hirst, S., Mu, Y., Pablo, J., Unal, B., Nakajima-Sasaki, R., Liang, X., Crotty, S., Karem, K. L., Damon, I. K., Ahmed, R., Villarreal, L., and Felgner, P. L. (2007) Proteome-wide analysis of the serological response to vaccinia and smallpox, Proteomics 7, 1678-1686.
Weaver, J. R., Shamim, M., Alexander, E., Davies, D. H., Felgner, P. L., and Isaacs, S. N. (2007) The identification and characterization of a monoclonal antibody to the vaccinia virus E3 protein, Virus Res 130, 269-274.
Benhnia, M. R., McCausland, M. M., Su, H. P., Singh, K., Hoffmann, J., Davies, D. H., Felgner, P. L., Head, S., Sette, A., Garboczi, D. N., and Crotty, S. (2008) Redundancy and plasticity of neutralizing antibody responses are cornerstone attributes of the human immune response to the smallpox vaccine, J Virol 82, 3751-3768.
Davies, D. H., Wyatt, L. S., Newman, F. K., Earl, P. L., Chun, S., Hernandez, J. E., Molina, D. M., Hirst, S., Moss, B., Frey, S. E., and Felgner, P. L. (2008) Antibody profiling by proteome microarray reveals the immunogenicity of the attenuated smallpox vaccine modified vaccinia virus ankara is comparable to that of Dryvax, J Virol 82, 652-663.
Jing, L., Davies, D. H., Chong, T. M., Chun, S., McClurkan, C. L., Huang, J., Story, B. T., Molina, D. M., Hirst, S., Felgner, P. L., and Koelle, D. M. (2008) An extremely diverse CD4 response to vaccinia virus in humans is revealed by proteome-wide T-cell profiling, J Virol 82, 7120-7134.
Sette, A., Moutaftsi, M., Moyron-Quiroz, J., McCausland, M. M., Davies, D. H., Johnston, R. J., Peters, B., Rafii-El-Idrissi Benhnia, M., Hoffmann, J., Su, H. P., Singh, K., Garboczi, D. N., Head, S., Grey, H., Felgner, P. L., and Crotty, S. (2008) Selective CD4+ T cell help for antibody responses to a large viral pathogen: deterministic linkage of specificities, Immunity 28, 847-858.
Jing, L., McCaughey, S. M., Davies, D. H., Chong, T. M., Felgner, P. L., De Rosa, S. C., Wilson, C. B., and Koelle, D. M. (2009) ORFeome approach to the clonal, HLA allele-specific CD4 T-cell response to a complex pathogen in humans, J Immunol Methods 347, 36-45.
Lantto, J., Hansen, M. H., Rasmussen, S. K., Steinaa, L.,Poulsen, T. R., Duggan, J., Dennis, M., Naylor, I., Easterbrook, L., Bregenholt, S., Haurum, J., and Jensen, A. (2011) Capturing the natural diversity of the human antibody response against Vaccinia virus, J Virol 85(4): 1820-1833.
Benhnia, M.R., Maybeno, M., Blum, D., Aguilar-Sino, R., Matho, M., Meng, X., Head, S., Felgner, P.L., Zajonc, D.M., Koriazova, L., Kato, S., Burton, D.R., Xiang, Y, Crowe, J.E., Peters, B., and Crotty, S. (2012) Unusual features of vaccinia virus extracellular virion form (EV) neutralization resistance revealed in human antibody responses to the smallpox vaccine, Journal of Virology 11/2012
Tan, X., Chun, S., Pablo, J., Felgner, P., Liang, X., and Davies, D. H. (2012) Failure of smallpox vaccine to take in vaccinia-naive individuals is related to differences in antibody profiles before vaccination, not after, Clin Vaccine Immunol 19(3):418-28.
Hermanson, G., Chun, S., Felgner, J., Tan, X., Pablo, J., Nakajima-Sasaki, R., Molina, D. M., Felgner, P. L., Liang, X., and Davies, D. H. (2012) Measurement of antibody responses to Modified Vaccinia virus Ankara (MVA) and Dryvax((R)) using proteome microarrays and development of recombinant protein ELISAs, Vaccine 30, 614-625.
Davies, D.H., Chun, S., Hermanson, G., Tucker, J.A., Jain, A., Nakajima, R., Pablo, J., Felgner, P.L., and Liang, X. (2014) T Cell Antigen Discovery Using Soluble Vaccinia Proteome Reveals Recognition of Antigens with Both Virion and Nonvirion Association, Journal of immunology (Baltimore, Md. : 1950). 07/2014
Pemphigus vulgaris
Kalantari-Dehaghi, M., Molina, D. M., Farhadieh, M., Morrow, W. J., Liang, X., Felgner, P. L., Grando, S. A. (2011) New targets of pemphigus vulgaris antibodies identified by protein array technology, Exp Dermatol 20, 154-156.
Kalantari-Dehaghi, M., Anhalt, G.J., Camilleri, M.J., Chernyavsky, A.I., Chun,S., Felgner, P.L., Jasinskas, A., Leiferman, K.M., Liang, L., Marchenko, S., Nakajima-Sasaki, R., Pittelkow, M.R., Zone, J.J., and Grando, S.A. (2013) Pemphigus vulgaris autoantibody profiling by proteomic technique, PLoS ONE 01/2013; 8(3):e57587.
Salmonella
Lee, S. J., Liang, L., Juarez, S., Nanton, M. R., Gondwe, E. N., Msefula, C. L., Kayala, M. A., Necchi, F., Heath, J. N., Hart, P., Tsolis, R. M., Heyderman, R. S., Maclennan, C. A., Felgner, P. L., Davies, D. H., and McSorley, S. J. (2012) Identification of a common immune signature in murine and human systemic Salmonellosis, Proc Natl Acad Sci U S A. 109(13):4998-5003.
Charles,R.C., Liang, L., Khanam, F., Sayeed, M.A., Hung, C., Leung, D.T., Baker, S., Ludwig, A., Harris, J.B., Larocque, R.C., Calderwood, S.B., Qadri, F., Felgner, P.L., and Ryan, E.T. (2013). Immunoproteomic analysis of antibody-in-lymphocyte supernatant (ALS) in patients with typhoid fever in Bangladesh, Clinical and vaccine Immunology: CVI 12/2013.
Liang, L., Juarez, S., Nga T.V.T., Dunstan, S., Nakajima-Sasaki, R., Davies, D.H., McSorley, S., Baker, S., and Felgner, P.L. (2013). Immune profiling with a Salmonella Typhi antigen microarray identifies new diagnostic biomarkers of human typhoid, Scientific Reports 01/2013; 3:1043.
Schistosomiasis
Driguez, P., Doolan, D. L., Loukas, A., Felgner, P. L., and McManus, D. P. (2010) Schistosomiasis vaccine discovery using immunomics, Parasit Vectors 3, 4.
Gaze, S., Driguez, P., Pearson, M.S., Mendes, T., Doolan, D.L., Trieu, A., McManus, D.P., Gobert, G.N., Periago,M.V., Oliveira,R.C., Cardoso, F.C., Oliveira,G., Nakajima, R., Jasinskas,A., Hung, C., Liang, L., Pablo, J., Bethony, J.M., Felgner, P.L., and Loukas, A. (2014) An immunomics approach to schistosome antigen discovery: antibody signatures of naturally resistant and chronically infected individuals from endemic areas, PLoS Pathogens 03/2014; 10(3):e1004033.
Pearson, M.S., Becker, L., Driguez, P., Young, N.D., Gaze, S., Mendes, T., Li, X-H., Doolan, D.L., Midzi, N., Mduluza, T., McManus, D.P., Wilson, R.A., Bethony, J.M., Nausch, N., Mutapi, F., Felgner, P.L., and Loukas, A. (2015) Of Monkeys and Men: Immunomic Profiling of Sera from Humans and Non-Human Primates Resistant to Schistosomiasis Reveals Novel Potential Vaccine Candidates, Frontiers in Immunology 05/2015; 6. DOI:10.3389/fimmu.2015.00213.
Driguez, P., McWilliam, H.E.G., Gaze, S., Piedrafita, D., Pearson, M.S., Nakajima, R., Duke, M., Trieu, A., Doolan, D.L., Cardoso, F.C., Jasinskas, A., Gobert, G.N., Felgner, P.L., Loukas, A., Meeusen, E., and McManus, D.P. (2015) Specific humoral response of hosts with variable schistosomiasis susceptibility, Immunology and Cell Biology 06/2015; DOI:10.1038/icb.2015.6.
Driguez, P., Li, Y., Gaze, S., Pearson, M.S., Nakajima, R., Trieu, A., Doolan, D.L., Felgner, P.L., Hou, X., Cardoso, F.C., Jasinskas, A., Gobert, G.N., Loukas, A., and McManus, D.P. (2015) Antibody Signatures Reflect Different Disease Pathologies in Patients With Schistosomiasis Due to Schistosoma japonicum, The Journal of Infectious Diseases 07/2015; DOI:10.1093/infdis/jiv356.
Staphylococcus aureus
Burnside, K., Lembo, A., Harrell, M.I., Klein, J.A., Lopez-Guisa, J., Siegesmund, A.M., Torgerson, T.R., Oukka,M., Molina,D.M., and Rajagopal, L. (2012) Vaccination with a UV-irradiated genetically attenuated mutant of Staphylococcus aureus provides protection against subsequent systemic infection, J Infect Dis, 206(11):1734-44..
Toxoplasmosis
Doskaya, M., Kalantari-Dehaghi, M., Walsh, C. M., Hiszczynska-Sawicka, E., Davies, D. H., Felgner, P. L., Larsen, L. S., Lathrop, R. H., Hatfield, G. W., Schulz, J. R., Guruz, Y., and Jurnak, F. (2007) GRA1 protein vaccine confers better immune response compared to codon-optimized GRA1 DNA vaccine, Vaccine 25, 1824-1837.
Liang, L., Doskaya, M., Juarez, S., Caner, A., Jasinskas, A., Tan, X., Hajagos, B. E., Bradley, P. J., Korkmaz, M., Guruz, Y., Felgner, P. L., and Davies, D. H. (2011) Identification of potential serodiagnostic and subunit vaccine antigens by antibody profiling of toxoplasmosis cases in Turkey, Mol Cell Proteomics 10, M110 006916.
Felgner, J., Juarez, S., Hung, C., Liang, L., Jain, A., Doskaya, M., Felgner, P.L., Caner, A., Guruz, Y., and Davies, D.H. (2014) Identification of Toxoplasma gondii antigens associated with different types of infection by serum antibody profiling, Parasitology doi:10.1017/S0031182014001978
General
Sundaresh, S., Doolan, D. L., Hirst, S., Mu, Y., Unal, B., Davies, D. H., Felgner, P. L., and Baldi, P. (2006) Identification of humoral immune responses in protein microarrays using DNA microarray data analysis techniques, Bioinformatics 22, 1760-1766.
Regis, D. P., Dobano, C., Quinones-Olson, P., Liang, X., Graber, N. L., Stefaniak, M. E., Campo, J. J., Carucci, D. J., Roth, D. A., He, H., Felgner, P. L., and Doolan, D. L. (2008) Transcriptionally active PCR for antigen identification and vaccine development: in vitro genome-wide screening and in vivo immunogenicity, Mol Biochem Parasitol 158, 32-45.
Vigil, A., Davies, D. H., and Felgner, P. L. (2010) Defining the humoral immune response to infectious agents using high-density protein microarrays, Future Microbiol 5, 241-251.
Molina DM, Liang X, Morrow WJW. (2010) Use of High-Throughput Proteomic Arrays for the Discovery of Disease-Associated Molecules. Biomarkers in Drug Development: A Handbook of Practice, Application, and Strategy. Wiley. Michael R. Bleavins (Editor), Claudio Carini (Editor), Mallé Jurima-Romet (Editor), Ramin Rahbari (Editor)
Magnan, C. N., Zeller, M., Kayala, M. A., Vigil, A., Randall, A., Felgner, P. L., and Baldi, P. (2010) High-throughput prediction of protein antigenicity using protein microarray data, Bioinformatics 26(23): 2936-2943.
Noroozi, Z., Kido, H., Peytavi, R., Nakajima-Sasaki, R., Jasinskas, A., Micic, M., Felgner, P. L., Madou, M. J. (2011) A multiplexed immunoassay system based upon reciprocating centrifugal microfluidics, Rev Sci Instrum 82, 064303.
Williams, T. N. (2011) How do hemoglobins S and C result in malaria protection?, J Infect Dis 204, 1651-1653.
Nuti, D.E., Crump, R.B., Handayani, F.D., Chantratita, N., Peacock, S.J., Bowen, R., Felgner, P.L., Davies, D.H., Wu, T., Lyons, C.R., Brett, P.J., Burtnick, M.N., Kozel, T.R., and AuCoin, D.P. (2011) Identification of circulating bacterial antigens by in vivo microbial antigen discovery, mBio 01/2011; 2(4).
Liang, L., and Felgner, P.L. (2012) Predicting antigenicity of proteins in a bacterial proteome; a protein microarray and naïve Bayes classification approach, Chemistry & Biodiversity 05/2012; 9(5):977-90.
Driguez, P., Doolan, D.L., Molina, D.M., Loukas, A., Trieu, A., Felgner, P.L., and McManus, D.P. (2015) Protein microarrays for parasite antigen discovery, Methods in molecular biology (Clifton, N.J.) 01/2015; 1201:221-33. DOI:10.1007/978-1-4939-1438-8_13.
King, C.L., Davies, D.H., Felgner, P., Baum, E., Jain, A., Randall, A., Tetteh, K., Drakeley, C.J., and Greenhouse, B. (2015) Biosignatures of Exposure/Transmission and Immunity, The American journal of tropical medicine and hygiene 08/2015; 93(3 Suppl). DOI:10.4269/ajtmh.15-0037.