VRDC

Protein Microarray Core

  • High Throughput (HT) Cloning and expression of proteins encoded by infectious microorganisms, printing probing and analysis of protein microarrays
  • Quantification of antibody responses by vaccines against individual antigens on a whole proteome scale
  • Formulation of bead vaccines for high throughput screen
  • Protein purification and formulation of Lead Candidate Antigens for Vaccine Optimization
  • Microarray training for external projects
  • Bioinformatics and Database Management

In vivo Imaging Core (Whole animal and Intravital Imaging

  • Understand lymphocyte movements induced by different infections infecting different target organs
  • Determine pharmacokinetic and pharmacodynamics of vaccines on a whole animal  and cellular scale
    • Different routes of administration
  • Add bioavailability and delivery knowledge to understand, control and improve vaccine efficacy

Recent Publications

Children with cerebral malaria or severe malarial anaemia lack immunity to distinct variant surface antigen subsets.

Related Articles

Sci Rep. 2018 Apr 19;8(1):6281

Authors: Travassos MA, Niangaly A, Bailey JA, Ouattara A, Coulibaly D, Lyke KE, Laurens MB, Pablo J, Jasinskas A, Nakajima R, Berry AA, Adams M, Jacob CG, Pike A, Takala-Harrison S, Liang L, Kouriba B, Kone AK, Rowe JA, Moulds J, Diallo DA, Doumbo OK, Thera MA, Felgner PL, Plowe CV

PMID: 29674705 [PubMed - in process]

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